John Maeda of MIT has gone through an interesting transformation career-wise going from computer science to art. That transformation has now led him to interesting insights into simplicity and complexity. Here's a recent talk of his on this topic. What I found most interesting is the insight that there is a lot complexity and simplicity in the world and humans like both, but in the right context. It is figuring out which context you're designing for that is the trick to great design.
Simplicity vs. Complexity
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